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Transgenic expression of dominant-negative mutant TRs, and the targeted gene inactivation or knockout of TR isoforms, have been used to study TH action in mice.
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Newborn screening for congenital hypothyroidism (CH) and early substitution treatment has eliminated mental retardation in children with CH ().
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However, there are no randomized placebo controlled trials of LT 4 therapy for bipolar disorder or depression, with or without concomitant antidepressant therapy.
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Daily oral cyclophosphamide-corticosteroid therapy is the initial favored treatment.
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