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What labs are required for clozapine? Before you can start clozapine and during treatment, you must have regular blood tests to measure the number of neutrophils you have in your blood. This test is called absolute neutrophil count (ANC). If the number of neutrophils, or ANC, is too low, you may have to stop clozapine.
Can you die from clozapine? Despite the range of life-threatening adverse reactions, clozapine is effective and well tolerated in many patients. One epidemiological study found that it reduced the risk of death, largely by reducing the suicide rate to a quarter of that found in past users of clozapine.
What can affect clozapine levels? There is no 'right' blood level of clozapine ; the aim is symptom control without toxicity. Higher blood levels of clozapine can cause sedation, hypotension and increased risk of neurological adverse effects including seizures. Other toxic effects of clozapine, including agranulocytosis, are not dose related.
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