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Interestingly, mean through imatinib plasma levels were significantly higher in an imatinib treated group of patients with complete cytogenetic response than in the group without and higher in the group with major molecular response than in the group without ().
COG also considers patients who are aged 13 years or older to be very high risk, although this age criterion is not utilized by other groups.
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The ultrasound image helps doctors determine if or how far the cancer has spread into nearby tissues.
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Additionally, one might consider patient age, mutation status, current quality of life, other diseases, quality and quantity of tissue used to measure mitotic rate, and surgical findings (whether it was multifocal, whether there was possible tumor rupture), or positive margins).
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Avoid concomitant strong CYP3A4 inducers (eg, rifampin): if needed, increase imatinib dose by at least 50%.
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