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Can prednisone cause adrenal insufficiency? Glucocorticoids such as prednisone, hydrocortisone, and dexamethasone are similar to natural hormones produced by the adrenal glands. Abrupt cessation of treatment with glucocorticoids is the most common cause of adrenal insufficiency. Other drugs that may cause adrenal insufficiency include the following: Megestrol.
How does a person get Addison's disease? Addison's disease is caused by an autoimmune response, which occurs when the body's immune system (which protects it from infection) assaults its own organs and tissues. With Addison's disease, the immune system attacks the outer portion of the adrenal glands (the cortex), where cortisol and aldosterone are made.
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